Killing Drug-Resistant Melanoma Requires Combination Therapy
نویسندگان
چکیده
منابع مشابه
Drug combination therapy increases successful drug repositioning.
Repositioning of approved drugs has recently gained new momentum for rapid identification and development of new therapeutics for diseases that lack effective drug treatment. Reported repurposing screens have increased dramatically in number in the past five years. However, many newly identified compounds have low potency; this limits their immediate clinical applications because the known, tol...
متن کاملDissecting resistance mechanisms in melanoma combination therapy
quiescent and physiological autophagy interact in response to therapies. Figure 2. A. Calibrating the model with in vitro data. B. Validating model predictions with in vitro combination therapy. Abstract— We present a compartment model that explains melanoma cell response and resistance to mono and combination therapies. Model parameters were estimated by utilizing an optimization algorithm to ...
متن کاملBedaquiline as part of combination therapy in adults with pulmonary multi-drug resistant tuberculosis.
INTRODUCTION Few innovative anti-microbial products have been brought to market in recent years to combat the global multidrug resistant-tuberculosis (MDR-TB) epidemic. Bedaquiline, a novel oral diarylquinoline, was approved by the US FDA as a part of combination therapy in adults with pulmonary MDR-TB based on phase II trials. AREA COVERED Pubmed searches were conducted using search terms be...
متن کاملMultifunctional Cu2−xTe Nanocubes Mediated Combination Therapy for Multi-Drug Resistant MDA MB 453
Hypermethylated cancer populations are hard to treat due to their enhanced chemo-resistance, characterized by aberrant methylated DNA subunits. Herein, we report on invoking response from such a cancer lineage to chemotherapy utilizing multifunctional copper telluride (Cu2-XTe) nanocubes (NCs) as photothermal and photodynamic agents, leading to significant anticancer activity. The NCs additiona...
متن کاملDrug unresponsiveness & combination therapy for kala-azar.
Pentavalent antimonials (SbV) have been successfully used for treatment of kala-azar since last six decades. Since 1970s its conventional dosages have failed to achieve with 60 per cent unresponsiveness reported with WHO regimen in Bihar (India). Pentamidine initially used as a second line of drug, acquired resistance (25%) even with prolonged dosage. Newer oral drug miltefosine is a potent ant...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: International Journal of Cancer Research
سال: 2011
ISSN: 1811-9727
DOI: 10.3923/ijcr.2011.155.156